Driving development and research with state-of-the-art imaging resources

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Driving development and research with state-of-the-art imaging resources

Get Started

Welcome to STTARR

The STTARR Innovation Centre brings together products, services and technologies to accelerate cutting-edge and multidisciplinary research in oncology, cardiology, metabolic diseases, and many other fields.

Flexible to the needs of our academic and industry clients, STTARR staff provides full support, from study conception to completion, including study design, budgeting, federal and provincial regulatory compliance, histopathology services, and advanced data analysis.

We focus on your success!

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6,642 ft2

Research Space

 

13+

Years of Experience

 

700+

Projects

 

1,800+

Researchers Working with STTARR

Innovation

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Cutting-edge technologies for multidisciplinary research

STTARR’s advanced imaging instruments and experimental capabilities include CT, MR, PET, SPECT, ultrasound, photoacoustics, optical, and radiation therapy. The STTARR Correlative Pathology Laboratory is equipped with innovative technology enabling whole-mount pathology, thus preserving the geometric integrity of the sample and ensuring accurate correlation to in vivo imaging in a systematic way.

STTARR also has animal holding rooms, a cell culture facility, and dedicated wet lab space for developing new contrast agents, molecular probes, and radiotracers.

Services

Sttarr offers the services and facilities needed for translational drug development and preclinical research.
Our services include:

For more information on Internal and External rates, please contact us or Manuela Ventura.

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Preclinical Imaging

Multimodal in vivo imaging in small and large animal models

  • Fluorescence and bioluminescence imaging
  • High resolution 3D ultrasound and photoacoustic imaging
  • Small animal 1T, and 7T MRI
  • Clinical 1.5T MRI for imaging large animals
  • MR-guided HIFU at 1.5T and 7T
  • PET-CT, PET-MR, SPECT-CT-PET
  • MicroCT imaging
  • Image-guided, flat-panel cone-beam CT radiation therapy units
  • Veterinary support through the Animal Resources Centre
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Radionuclides and Radiotracers

  • STTARR has expertise in:
    • radiolabeling proteins, antibodies, antibody fragments, liposomes, and other nanoparticles in one of its two Intermediate Level laboratories
    • performing pharmacokinetic and biodistribution studies
    • positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging
  • The STTARR Innovation Centre has a nuclear substances permit to possess, transfer, store and use:
    Ac-225, Cu-64, F-18, Ga-67, Ga-68, I-123, I-125, In-111, Lu-177, Mn-52, Tc-99m, Y-86, Y-90, and Zr-89
  • PET Radiotracers can be obtained from affiliates or commercial sources:
    F-18 FDG, F-18 FAZA, F-18 FCholine, F-18 DCFPyL(PSMA), F-18 Sodium Fluoride (NaF), and F-18 FLT
  • A selection of SPECT radiotracers include, but is not limited to the following: Tc-99m pertechnetate, Tc-99m MDP and Tc-99m MIBI

If your isotope or tracer is not mentioned, please talk to us!

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Histopathology

The STTARR Pathology Core services all research laboratories within UHN, academic institutes and industry sponsors on pre-clinical research projects with full Histopathology services.
These services includes:

▸ Formalin fixed Paraffin embedded (FFPE) tissue services
  • Grossing

    Inspect the samples for fixation statues, trimming harvest tissue to the plain of interest.

  • Tissue processing & embedding (regular and wholemount)

    Regular cassettes size is 30mm x 35mm.
    Supersize cassette for wholemount is 65mmX50mm.

  • Re-embedding

    Melt down paraffin block and re-orient the tissue into the desire cutting plain.

▸ Frozen tissue services
  • Cryo block sectioning

    Sectioning OCT frozen tissue blocks prepared by users.

  • Regular tissue specimen Freezing

    User provide fresh harvested tissue to STTARR Pathology for snap freezing in OCT.

  • Muscle Specimen Freezing

    Special snap freezing technique for muscle tissue prone to freeze artifact.

▸ Microtomy
  • Microtomy

    Sectioning paraffin and frozen section at routine 4um thickness or in special thickness requested by user.

  • Paraffin Microtomy

    Regular slides: 25mmx75mm.
    Wholemount large slide:50mmx75mm.

  • Serial sections

    Paraffin or frozen (per slide) consecutive sections from a ribbon of section mounted on slides labelled with numbers.

  • Specific micro-structure/Precise sectioning

    Look for specific microscopic structures in paraffin/frozen blocks and take sections eg. Mouse aortic arch, aortic root, mouse embryo thyroid glands.

▸ Immunohistochemistry
  • IHC New Antibody Optimization

    Optimization of commercial and/or in house produced antibodies.

  • Immunohistochemistry

    Check out our Pathology Optimized Antibody List for a list of antibodies currently available and optimized at STTARR Pathology. Please note that the list is continuously updated. If the antibody you are interested in is not on the list, please contact us.

  • Multiplex IF staining

    Multiplex of up to 3 target proteins in cells/tissues using flourescent tagged antibodies.

  • Tunel assay

    Detection of DNA fragmentation in last phase of apoptosis (cell death).

▸ In situ hybridization
  • In Situ Hybridization (RNAscope)

    Uitlizing ACDBio System probes and detection systems to detect target mRNA in paraffin embedded sections.

▸ Special Stains
  • Special Stains & Enzyme Histochemistry

    Masson trichrome, Elastic Trichrome, Picrosirius red,Periodic acid Schiff, Cresyl echt violet, Luxol fast blue, Gram stain, von Kossa calcium, Oil O red, Gordon & Sweets Siliver Reticular fiberstain, Safranin O and fast green, TRAP(Tartaric Acid Resistant Phosphotase).
    STTARR Pathology has other histochemistry stain protocols that are available upon request, please inquire if the stain that you are interested is not on the list.

▸ H&E staining

Principle and routine stain used in histopathology perform on paraffin or frozen sections.

▸ Other services
  • Autoradiography

    Sectioning thick sections (3--50microns) for autoradiography, 2 sets of slides each sample. Protocol on sample preparation for autoradiography available upon request.

  • Cell pellet agar embedding

    Centrifuge cell pellet and double embed into agar gel and paraffin.

  • Decalcification- acid

    Formic acid for rapid decalcification or EDTA for tissue to be used for IHC.

  • Full necropsy (Mouse, Rat, guinea pig)

    Havest tissue for toxicology study or specific organ of interest.

  • Tissue microarray construction

    Combining multiple donor tissue parrafin blocks into one for high throughput IHC staining.

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Data Visualization, Analysis & Quantification

Pathology and correlative image analysis

  • Digital pathology analysis, including software for brightfield and fluorescence microscopy analysis
  • Radiology image analysis of 3D medical images from STTARR facility scanners
  • In-house image processing and data analysis services for novel modalities or research avenues such as imaging mass cytometry analysis
  • Analysis software training
  • High-resolution whole slide scanning
  • Large file storage on backed-up servers
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Consulting & Education

Scientific consulting & project management, workshops, user training and facility tours available

  • Our scientists provide comprehensive support throughout study conception, project management, method development, data analysis, and scientific & grant writing
  • We offer workshops on molecular imaging, user training sessions and facility tours. Please contact us for personalized workshop and training opportunities
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Translational Infrastructure

  • With two fully equipped operating rooms, intraoperative imaging capabilities (Fluoroscopy, Fluorescence Imaging), and a clinical bore size MRI with HIFU, STTARR provides infrastructure and offers support for translational research

Access

ONLINE FORMS

Equipment

Our equipment is designed to facilitate multidisciplinary collaborations.

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CT

CT combines a series of x-ray images taken from different angles around the subject or animal. Taking advantage of the differences in the x-ray attenuation properties of the various tissues and organs, computer processing creates cross-sectional images (slices) of the internal structures.

▸ Bruker SkyScan 1276
  • The Bruker SkyScan 1276 microCT system, located at UHN’s Krembil Discovery Tower and operated by STTARR, supports whole-body anatomical imaging of mice and rats in vivo, as well as high resolution studies of small excised samples (e.g. mouse femur, tibia) and non-biological samples
  • The SkyScan 1276 microCT has a maximum scan field of view that is 80 mm wide and more than 300 mm long. The highest nominal spatial resolution achievable is 2.8 µm pixel size for bone and tissue samples and approximately 10 µm for in vivo mouse studies
  • Physiological monitoring for time-resolved CT imaging (e.g. cardiac and respiratory gating) is available
▸ Mediso CT (As part of the SPECT-CT-PET trimodal system)
  • Mediso nanoScan SPECT-CT-PET is a triple modality system which also supports whole-body anatomical imaging of mice and rats at STTARR. CT scans can be easily co-registered to corresponding SPECT or PET scans
  • A 10 µm isotropic voxel size is the highest resolution possible for small (< 2 cm) field-of-view CT scans
▸ Clinical CT – 2020, Coming Soon
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MRI

A MRI scan uses the magnetization from water protons to generate images in which brightness can reflect not only the density of water protons in tissue but also the interaction of water protons with their local microenvironment. These images provide an unparalleled soft tissue contrast, enabling both anatomic and functional imaging for monitoring tumor growth and response to therapies.

▸ 7 Tesla MRI (Biospec, Bruker)
  • By utilizing a range of RF and gradient coil inserts, it can accomodate animal models ranging in scale from ex vivo tissue samples and rodents, through to 5-7 kg animals
  • The machine capabilities are model-dependent, but can range from MR microscopy tasks (i.e. 60-micron isotropic voxels, using optimized RF coils and prolonged scanning sessions) through to standard techniques at high resolution for the relevant anatomy (i.e. 100x100x500-micron voxels in time-efficient murine brain scans; 500x500x1500-micron voxels in primates)
  • The STTARR-MRI can also accomodate multi-modal MR/CT/PET imaging in rodents utilizing the Minerve Small Animal Environment System
▸ 1 Tesla MRI (M3, Aspect Imaging)
  • It is well suited for multi-modal applications, and we have experience with such as 3D registration of the MR data sets to PET (Siemens Focus 220) and BLI (Xenogen IVIS) data sets
  • The M3 is currently used at STTARR for T1 and T2-weighted anatomical imaging, as well as dynamic contrast enhanced (DCE) imaging of tissue perfusion and permeability
  • The system is equipped with two RF body coils and a RF head coil for murine imaging applications
▸ 1.5 Tesla MRI (Aera, Siemens)
  • Siemens 1.5T Aera is an equivalent MRI system to one that might be found in a clinical radiology department
  • At STTARR, it serves as a platform for development of MR-guided therapeutics, including MR-guided high intensity focused ultrasound, and with its 70 cm bore diameter and clinically-standard selection of RF coils and MRI pulse sequences, it allows for comprehensive imaging in larger animal models
  • STTARR also maintains a research standard level of system access to enable technical MRI research and development
▸ MRgHIFU (LabFUS, Image Guided Therapy)
  • STTARR provides MR-guided high intensity focused ultrasound for both the 7 Tesla Bruker Biospec and 1.5 Tesla Siemens Aera MRI systems
  • The small animal MRgHIFU system for the Biospec includes two 25-mm diameter 8-element annular array transducers; a 1.5 MHz transducer suited for blood brain barrier disruption, and a 2.5 MHz transducer appropriate for hyperthermia or ablation applications. The large animal system includes a 145-mm diameter 256-element phased-array transducer operating at 1 MHz
  • For both small animal and large animal platforms, MRgHIFU feedback control based on real-time MR thermometry can be implemented through Proteus software
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Molecular Imaging

The nuclear medicine modalities of PET (Positron Emission Tomography) and SPECT (Single Photon Emission Computed Tomography) rely on injection (or sometimes inhalation) of a radioactive tracer. Nuclear medicine and molecular imaging techniques provide unique insight into the visualization, characterization, and measurement of biological processes at the molecular and cellular levels.

PET is a nuclear medicine imaging modality that detects the emissions of radiolabelled tracers. As positron-emitting isotopes decay, positrons interact with electrons in the subject. When a positron and electron interact, an annihilation event occurs in which the mass of these subatomic particles is converted into energy (E = mc2) in the form of two 511 keV gamma rays emitted at 180° apart from each other. These gamma ray pairs, resulting from annihilation events, are what is detected by the PET scanner.

SPECT is an imaging technique based on the detection of gamma rays emitted by radioactive tracers. The scanner consists of four gamma camera heads (scintillating sodium iodide crystals doped with thallium) with pinhole collimators that rotate around the subject. The SPECT computer reconstructs a 3-D tomographic image from the acquisition of 2-D images at multiple angles (projections). Isotopes useful for SPECT imaging emit gamma rays with energies between ~25 – 250 keV. They are high atomic number metals commonly used to label molecules of biological significance.

▸ PET/MRI – Mediso NanoScan
  • The Mediso NanoScan PET/MRI supports whole-body anatomic and physiological dynamic mouse and rat imaging at STTARR, including cardiac and respiratory gated PET and MRI
  • PET specifications: 0.9 mm spatial resolution (with reconstructed voxel sizes of 0.3, 0.4 or 0.6 mm)
  • MR specifications: 1 Tesla MRI, Gradient strength 450 mT/m, spatial resolution ≤ 100 µm with integrated gradient coil, RF and magnetic shielding
▸ SPECT-CT-PET – Mediso NanoScan
  • The Mediso NanoScan SPECT/CT/PET trimodal system supports whole-body mouse and rat imaging at STTARR. Dual-isotope SPECT imaging as well as gated SPECT and PET acquisitions are possible
  • SPECT parameters: spatial resolution varies depending on selected collimators, e.g. 1.1 mm (mouse - ultra-high sensitivity), 0.6 mm (mouse - ultra-high resolution) and 1 mm for rats
  • PET parameters: 0.9 mm spatial resolution (reconstructed voxel options: 0.3, 0.4 or 0.6 mm)
  • CT parameters: 10 µm minimum voxel size for a small field-of-view (e.g. mouse vertebra). Typically, a whole-body mouse CT takes less than 5 minutes for acquisition and reconstruction
▸ Wallac 1480 Wizard Gamma-Counter – PerkinElmer
  • The Wallac 1480 Wizard gamma-counter is an indispensible instrument for any pharmacokinetic or biodistribution experiment
  • 4π counting geometry for optimum efficiency, i.e. a 3-inch NaI(Tl) crystal surrounded by 3 inches of lead shielding, thus impenetrable to background radiation and crosstalk
  • Perfect for high energy (15 keV – 2 MeV), low activity samples
  • The researcher can count up to 20 mL/sample and up to 1000 samples/run using a library of 51 radionuclides
  • Counting racks can accommodate from 12×75 mm test tubes to 25 mm-diameter liquid scintillation vials
  • 2048-channel multichannel analyzer capable of back-decay and spilldown corrections
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Optical

Fluorescence and Bioluminesence imaging techniques.

▸ PerkinElmer Xenogen IVIS Spectrum Imaging System
  • Xenogen bioluminescence imaging provides the ability to detect luciferase-expressing cells with a high degree of sensitivity, making it particularly useful in for lower numbers of cells, for which fluorescence imaging may not be sensitive enough to separate signal from background autofluorescence
  • The quantitative or semi-quantitative nature of bioluminescence imaging also allows the tracking of the number of cells (or degree of luciferase expression) over time, with multiple injections of luciferin, lending itself well to applications such as monitoring of tumor burden over time
▸ CRI Maestro System
  • The CRI Maestro system is best used with known fluorophores, or transgenic cells expressing a fluorescent protein, growing subcutaneously within the murine model
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Ultrasound

Real-time images are generated by applying high-frequency sound and then detecting the returning sound waves (echoes) caused by differences in acoustic impedence of the various tissue interfaces within the subject of interest. In addition to 2D B-mode images, anatomical 3D images of a small region can also be obtained. If the ultrasound beam is directed into a blood vessel, the blood flow gradient can be measured by a technique known as the Doppler effect. Visualization of blood flow can be further enhanced by the use of acoustic contrast agents such as microbubbles.

▸ Visualsonics Vevo 2100 System
  • Operates at frequency (20 to 40MHz) an order of magnitude above what is typically used in the clinic (1 to 5 MHz), which improves the resolution which is crucial for imaging small structures of a mouse
  • Features include 2D and 3D imaging, non-linear contrast imaging, M-mode, colour Doppler as well as pulsed-wave and continuous-wave Doppler
  • Transducers for mice and rat interrogation are the MS250 (13-24 MHz) and MS550D (22-55 MHz)
  • Heated mouse platform for regulating temperature and ECG-gating
  • Ultrasound-guided biopsy instrumentation
  • Vevo LAB software for quantifying and characterizing disease progression with specific applications
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PhotoAcoustics

The photoacoustic (PA) effect refers to the generation of acoustic waves from an object being illuminated by pulsed or modulated electromagnetic (EM) radiation, including optical waves. The fundamental principle of the PA effect is based on the thermal expansion resulting from the absorption of EM radiation. The thermal expansion increases the acoustic pressure in the medium. Pulsing or modulating the EM radiation generates an acoustic wave which can be detected using an ultrasound transducer.

▸ Visualsonics Vevo LAZR Photoacoustic Imaging System
  • A multi-component system which integrates laser light delivery with ultrasound image acquisition to produce photoacoustic image data
  • Uses a 20Hz tunable laser (680 – 970nm) to image functional hemodynamic and molecular data with a resolution down to 40 µm and a depth of 1 cm
  • Transducers for mice and rat interrogation are the MZ250 (13-24 MHz) and MZ550 (32-55 MHz)
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Small Animal Irradiator

The X-Rad225 provides mid-range energy for high and low dose rate irradiation studies. A wide range of collimators are available for high precision targeting.

▸ Precision X-Ray X-RAD 225Cx
  • The Precision X-Ray X-RAD 225Cx irradiator enables irradiation of cells and small animals (ranging from mice to rabbits)
  • The X-RAD’s cone-beam CT allows for precision image-guided irradiations
  • MR images can be imported and co-registered to CT images, for precision image-guided irradiations
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Software and Analysis Workstations

STTARR’s Image Analysis Core provides both self-service workstations and dedicated technician analysis of medical images coming from the STTARR facility scanners, as well as digital pathology and mass spectrometry image analysis. Our team can guide you through the available options and provide software training as needed.

▸ High-performance computing workstations
  • 6 computer workstations are available with a wide variety of analysis software
  • General specs: Intel Xeon CPUs, 32 GB RAM, CUDA-enabled NVIDIA GPUs
  • High-speed on-site data server allows for secure large file storage
▸ Pathology image analysis software
  • Commercial software packages can be used for high-throughput analysis of digitized whole slide images including performing classification of various tissue types and cell counting
  • HALO by Indica Labs
  • Visiopharm
  • Definiens TissueStudio and Developer
▸ Radiology image analysis software
  • Siemens Inveon Research Workplace (IRW)
  • InviCRO VivoQuant volumetric analysis software

Team

picture of Manuela Ventura

Manuela Ventura, PhD

Research Program Manager
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Deborah Scollard

Imaging Core Manager
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Trevor McKee, PhD

Image Analysis Core Manager
picture of Napoleon Law

Napoleon Law

Pathology Core Manager
picture of Warren Foltz

Warren Foltz, PhD

MRI Lead
picture of Teesha Komal

Teesha Komal

Imaging Technologist
picture of Luke Kwon

Luke Kwon, PhD

Scientific Associate
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Russell Shen, PhD

Scientific Associate
picture of Veronica Cojocari

Veronica Cojocari

Image Analyst
picture of Feryal Sarraf

Feryal Sarraf

Histotechnologist
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Jordi Ros Rodriguez

Histotechnologist
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Doug Vines

Nuclear Imaging Scientist
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Steve Ansell

Computational Consultant
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Catherine Williams

Administrative Assistant

Publications

We kindly request for authors who use STTARR resources to include the following acknowledgement in their publication:
“The authors would like to acknowledge the Spatio-Temporal Targeting and Amplification of Radiation Response (STTARR) program and its affiliated funding agencies.”

Select a year to see a listing of articles published.

  1. Rezaeeyan, H., Shirzad, R., McKee, T. D., & Saki, N. (2018). Role of chemokines in metastatic niche: new insights along with a diagnostic and prognostic approach. Apmis.
  2. Alhamami, M., Cheng, W., Lyu, Y., Allen, C., Zhang, X.A. and Cheng, H.L.M., 2018. Manganese-porphyrin-enhanced MRI for the detection of cancer cells: A quantitative in vitro investigation with multiple clinical subtypes of breast cancer. PloS one, 13(5), p.e0196998.
  3. Bteich, J., Ernsting, M.J., Mohammed, M.Z., Kiyota, T., McKee, T., Trikha, M., Lowman, H. and Sokoll, K.K., 2018. A Novel Nanoparticle Formulation Derived from Carboxymethyl-Cellulose, Polyethylene Glycol and Cabazitaxel for Chemotherapy Delivery to the Brain. Bioconjugate chemistry.
  4. Dhani, N.C., Lohse, I., Foltz, W.D., Cao, P.J. and Hedley, D.W., 2018. Estimating tumour volume in a primary orthotopic mouse model of human pancreatic cancer using rapid acquisition magnetic resonance imaging. journal of cancer therapeutics and research, 3(1), p.9.
  5. Rezaeeyan, H., Shahrabi, S., McKee, T.D. and Saki, N., 2018. The expression of CD markers in solid tumors: Significance in metastasis and prognostic value. Histology and histopathology, pp.11981-11981.
  6. Li, H., Xie, Y., Liu, Y., Qi, Y., Tang, C., Li, X., Zuo, K., Sun, D., Shen, Y., Pang, D. and Chu, Y., 2018. Alteration in microRNA-25 expression regulate cardiac function via renin secretion. Experimental cell research, 365(1), pp.119-128.
  7. He, C., Li, J., Cai, P., Ahmed, T., Henderson, J.T., Foltz, W.D., Bendayan, R., Rauth, A.M. and Wu, X.Y., 2018. Two‐Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2‐Positive Breast Cancer. Advanced Functional Materials.
  8. Shahin, S.A., Wang, R., Simargi, S.I., Contreras, A., Echavarria, L.P., Qu, L., Wen, W., Dellinger, T., Unternaehrer, J., Tamanoi, F. and Zink, J.I., 2018. Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer. Nanomedicine: Nanotechnology, Biology and Medicine, 14(4), pp.1381-1394.
  9. Teichman, J., Dodbiba, L., Thai, H., Fleet, A., Morey, T., Liu, L., McGregor, M., Cheng, D., Chen, Z., Darling, G. and Brhane, Y., 2018. Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma. PloS one, 13(5), p.e0194809.
  10. Haynes, J., McKee, T.D., Haller, A., Wang, Y., Leung, C., Gendoo, D.M., Lima-Fernandes, E., Kreso, A., Wolman, R., Szentgyorgyi, E. and Vines, D.C., 2018. Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer. Clinical Cancer Research.
  11. Beera, K.G., Li, Y.Q., Dazai, J., Stewart, J., Egan, S., Ahmed, M., Wong, C.S., Jaffray, D.A. and Nieman, B.J., 2018. Altered brain morphology after focal radiation reveals impact of off-target effects: implications for white matter development and neurogenesis. Neuro-oncology, 20(6), pp.788-798.
  12. Zanette, B., Stirrat, E., Jelveh, S., Hope, A. and Santyr, G., 2018. Physiological gas exchange mapping of hyperpolarized 129Xe using spiral‐IDEAL and MOXE in a model of regional radiation‐induced lung injury. Medical physics, 45(2), pp.803-816.
  13. Tang, Q., Lu, J., Zou, C., Shao, Y., Chen, Y., Narala, S., Fang, H., Xu, H., Wang, J., Shen, J. and Khokha, R., 2018. CDH4 is a novel determinant of osteosarcoma tumorigenesis and metastasis. Oncogene, p.1.
  14. Yang, C., Bromma, K., Ciano-Oliveira, C., Zafarana, G., Prooijen, M. and Chithrani, D.B., 2018. Gold nanoparticle mediated combined cancer therapy. Cancer Nanotechnology, 9(1), p.4.
  15. Inoue, M., Enomoto, M., Koike, Y., Di Grappa, M.A., Zhao, X., Yip, K., Huang, S.H., Waldron, J.N., Ikura, M., Liu, F.F. and Bratman, S.V., 2018. Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis. bioRxiv, p.273037.
  16. Xia, D., Casanova, R., Machiraju, D., McKee, T.D., Weder, W., Beck, A.H. and Soltermann, A., 2018. Computationally-Guided Development of a Stromal Inflammation Histologic Biomarker in Lung Squamous Cell Carcinoma. Scientific reports, 8(1), p.3941.
  17. Dunne, Michael, Yannan N. Dou, Danielle M. Drake, Tara Spence, Sávio ML Gontijo, Peter G. Wells, and Christine Allen. “Hyperthermia-mediated drug delivery induces biological effects at the tumor and molecular levels that improve cisplatin efficacy in triple negative breast cancer.” Journal of Controlled Release (2018).
  18. Young, M., Rodenhizer, D., Dean, T., D’Arcangelo, E., Xu, B., Ailles, L. and McGuigan, A.P., 2018. A TRACER 3D Co-Culture tumour model for head and neck cancer. Biomaterials, 164, pp.54-69.
  19. Aghevlian, S., Lu, Y., Winnik, M.A., Hedley, D.W. and Reilly, R.M., 2018. Panitumumab Modified with Metal-Chelating Polymers (MCP) Complexed to 111In and 177Lu–An EGFR-Targeted Theranostic for Pancreatic Cancer. Molecular pharmaceutics.
  20. Yao, W., Xia, K. and Liu, H.W., 2018. Influence of heating on the dynamic tensile strength of two mortars: Experiments and models. International Journal of Impact Engineering, 122, pp.407-418.
  21. Haynes, J., McKee, T.D., Haller, A., Wang, Y., Leung, C., Gendoo, D.M., Lima-Fernandes, E., Kreso, A., Wolman, R., Szentgyorgyi, E. and Vines, D.C., 2018. Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer. Clinical Cancer Research.
  22. Stapleton, S., Dunne, M., Milosevic, M., Tran, C.W., Gold, M.J., Vedadi, A., Mckee, T.D., Ohashi, P.S., Allen, C. and Jaffray, D.A., 2018. Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics. ACS nano, 12(8), pp.7583-7600.
  23. Bernards, N., Ventura, M., Fricke, I.B., Hendriks, B.S., Fitzgerald, J., Lee, H. and Zheng, J., 2018. Liposomal Irinotecan Achieves Significant Survival and Tumor Burden Control in a Triple Negative Breast Cancer Model of Spontaneous Metastasis. Molecular Pharmaceutics, 15(9), pp.4132-4138.
  24. Belliveau, J.G., Jensen, M.D., Stewart, J.M., Solovey, I., Klassen, L.M., Bauman, G.S. and Menon, R.S., 2018. Prediction of radiation necrosis in a rodent model using magnetic resonance imaging apparent transverse relaxation (). Physics in Medicine & Biology, 63(3), p.035010.
  25. Yoshida, M., Oishi, H., Martinu, T., Hwang, D.M., Takizawa, H., Sugihara, J., McKee, T.D., Bai, X., Guana, Z., Lua, C. and Cho, H.R., 2018. Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model. Oncotarget, 9(9), p.8489.
  26. Yang, C., Bromma, K., Di Ciano-Oliveira, C., Zafarana, G., van Prooijen, M. and Chithrani, D.B., 2018. Gold nanoparticle mediated combined cancer therapy. Cancer Nanotechnology, 9(1), p.4.
  27. Tang, Q., Lu, J., Zou, C., Shao, Y., Chen, Y., Narala, S., Fang, H., Xu, H., Wang, J., Shen, J. and Khokha, R., 2018. CDH4 is a novel determinant of osteosarcoma tumorigenesis and metastasis. Oncogene, p.1.
  28. Harmatys, K.M., Overchuk, M., Chen, J., Ding, L., Chen, Y., Pomper, M.G. and Zheng, G., 2018. Tuning Pharmacokinetics to Improve Tumor Accumulation of a Prostate-Specific Membrane Antigen-Targeted Phototheranostic Agent. Bioconjugate Chemistry, 29(11), pp.3746-3756.
  29. Keca, J.M., Valic, M.S., Cheng, M.H., Jiang, W., Overchuk, M., Chen, J. and Zheng, G., 2018. Mixed and Matched Metallo‐Nanotexaphyrin for Customizable Biomedical Imaging. Advanced healthcare materials, p.1800857.
  30. Al-saden, N., Cai, Z. and Reilly, R.M., 2018. Tumor uptake and tumor/blood ratios for 89Zr-DFO-trastuzumab-DM1 on microPET/CT images in NOD/SCID mice with human breast cancer xenografts are directly correlated with HER2 expression and response to trastuzumab-DM1. Nuclear medicine and biology, 67, pp.43-51.
  31. Al-Saden, N., Lam, K., Chan, C. and Reilly, R.M., 2018. Positron-Emission Tomography of HER2-Positive Breast Cancer Xenografts in Mice with 89Zr-Labeled Trastuzumab-DM1: A Comparison with 89Zr-Labeled Trastuzumab. Molecular pharmaceutics, 15(8), pp.3383-3393.
  32. Islam, D., Huang, Y., Fanelli, V., Delsedime, L., Wu, S., Khang, J., Han, B., Grassi, A., Li, M., Xu, Y. and Luo, A., 2018. Identification and Modulation of Microenvironment is Crucial for Effective MSC Therapy in Acute Lung Injury. American journal of respiratory and critical care medicine, (ja).
  1. Matsumoto, Y., La Rose, J., Lim, M., Adissu, H.A., Law, N., Mao, X., Cong, F., Mera, P., Karsenty, G., Goltzman, D. and Changoor, A., 2017. Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism. The Journal of clinical investigation, 127(7), pp.2612-2625.
  2. ui, L., Her, S., Borst, G.R., Bristow, R.G., Jaffray, D.A. and Allen, C., 2017. Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?. Radiotherapy and Oncology, 124(3), pp.344-356.
  3. Cui, L., Her, S., Dunne, M., Borst, G.R., De Souza, R., Bristow, R.G., Jaffray, D.A. and Allen, C., 2017. Significant radiation enhancement effects by gold nanoparticles in combination with cisplatin in triple negative breast cancer cells and tumor xenografts. Radiation research, 187(2), pp.147-160.
  4. Allen, C., Her, S. and Jaffray, D.A., 2017. Radiotherapy for Cancer: Present and Future. Advanced drug delivery reviews, 109, p.1.
  5. Zhang, L., Vines, D.C., Scollard, D.A., McKee, T., Komal, T., Ganguly, M., Do, T., Wu, B., Alexander, N., Vali, R. and Shammas, A., 2017. Correlation of Somatostatin Receptor-2 Expression with Gallium-68-DOTA-TATE Uptake in Neuroblastoma Xenograft Models. Contrast media & molecular imaging, 2017.
  6. Cai, Z., Lai, P., Yook, S., Lu, Y., Scollard, D., Winnik, M., Pignol, J.P. and Reilly, R., 2017. Auger-gold-A novel radiation nanomedicine for treatment of small metastases from triple-negative breast cancer. Journal of Nuclear Medicine, 58(supplement 1), pp.677-677.
  7. Wilcox, J.T., Satkunendrarajah, K., Nasirzadeh, Y., Laliberte, A.M., Lip, A., Cadotte, D.W., Foltz, W.D. and Fehlings, M.G., 2017. Corrigendum to” Generating level-dependent models of cervical and thoracic spinal cord injury: Exploring the interplay of neuroanatomy, physiology, and function” Neurobiology of Disease 105 (2017) 194-212. Neurobiology of disease, 108, p.363.
  8. Chaudary, N., Cheung, M., Foltz, W.D., Abdalaty, A.H., Stewart, J.M.P., Lindsay, P.E., Siddiqui, I., Larsen, M., Hill, R.P., Milosevic, M. and Kim, J.H., 2017. Preclinical Development of Targeted Stereotactic Body Radiation Therapy for Pancreatic Cancer. International Journal of Radiation Oncology• Biology• Physics, 99(2), p.S192.
  9. Kalman, N.S., Hugo, G.D., Kahn, J., Zhao, S., Jan, N., Mahon, R.N. and Weiss, E., 2017. Interobserver Reliability in Describing Radiographic Lung Changes After Stereotactic Body Radiation Therapy. International Journal of Radiation Oncology• Biology• Physics, 99(2), p.S196.
  10. Kwon, L.Y., Scollard, D.A. and Reilly, R.M., 2017. 64Cu-Labeled Trastuzumab Fab-PEG24-EGF Radioimmunoconjugates Bispecific for HER2 and EGFR: Pharmacokinetics, Biodistribution, and Tumor Imaging by PET in Comparison to Monospecific Agents. Molecular pharmaceutics, 14(2), pp.492-501.
  11. Lee, S.L., Foltz, W.D., Lee, J., Craig, T., Berlin, A., Chung, P. and Menard, C., 2017. Changes in Apparent Diffusion Coefficient of the Dominant Tumor During Dose-Painted Radiation Therapy and High Dose Rate Brachytherapy for Prostate Cancer. International Journal of Radiation Oncology• Biology• Physics, 99(2), p.E684.
  12. He, C., Li, J., Cai, P., Ahmed, T., Henderson, J.T., Foltz, W.D., Bendayan, R., Rauth, A.M. and Wu, X.Y., 2018. Two‐Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2‐Positive Breast Cancer. Advanced Functional Materials.
  13. Coolens, C., Driscoll, B., Foltz, W.D., Sinno, N. and Chung, C., 2017. Voxelwise Perfusion and Diffusion Evaluated in Multimodal Imaging Following Radiosurgery for Metastatic Brain Cancer. International Journal of Radiation Oncology• Biology• Physics, 99(2), pp.S195-S196.
  14. Lee, J.K., Zhai, T., Jackson, P., Wen, N. and Siddiqui, S., 2017. Patient Immobilization for Stereotactic Radiosurgery in the Treatment of Malignancies of the Cervical Spine: 9-Point Mask Versus Non-9-Point Mask Immobilization System. International Journal of Radiation Oncology• Biology• Physics, 99(2), pp.E683-E684.
  15. Hysi, E., Wirtzfeld, L. A., May, J. P., Undzys, E., Li, S. D., & Kolios, M. C. (2017). Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation. Photoacoustics, 5, 25-35.
  16. Beera, K.G., Li, Y.Q., Dazai, J., Stewart, J., Egan, S., Ahmed, M., Wong, C.S., Jaffray, D.A. and Nieman, B.J., 2017. Altered brain morphology after focal radiation reveals impact of off-target effects: implications for white matter development and neurogenesis. Neuro-oncology, p.nox211.
  17. Bullova, P., Cougnoux, A., Marzouca, G., Kopacek, J. and Pacak, K., 2017. Bortezomib alone and in combination with salinosporamid A induces apoptosis and promotes pheochromocytoma cell death in vitro and in female nude mice. Endocrinology, 158(10), pp.3097-3108.
  18. Anderson, J.L., Muraleedharan, R., Oatman, N., Klotter, A., Sengupta, S., Waclaw, R.R., Wu, J., Drissi, R., Miles, L., Raabe, E.H. and Weirauch, M.L., 2017. The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas. Neuro-oncology, 19(8), pp.1068-1078.
  19. Takayama, K., Inoue, T., Narita, S., Maita, S., Huang, M., Numakura, K., Tsuruta, H., Saito, M., Maeno, A., Satoh, S. and Tsuchiya, N., 2017. Inhibition of the RANK/RANKL signaling with osteoprotegerin prevents castration-induced acceleration of bone metastasis in castration-insensitive prostate cancer. Cancer letters, 397, pp.103-110.
  20. Lin, G.H., Chai, V., Lee, V., Dodge, K., Truong, T., Wong, M., Johnson, L.D., Linderoth, E., Pang, X., Winston, J. and Petrova, P.S., 2017. TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets. PloS one, 12(10), p.e0187262.
  21. Yao, W., Liu, H.W., Xu, Y., Xia, K. and Zhu, J., 2017. Thermal degradation of dynamic compressive strength for two mortars. Construction and Building Materials, 136, pp.139-152.
  22. Zanette, B., Stirrat, E., Jelveh, S., Hope, A. and Santyr, G., 2017. Physiological gas exchange mapping of hyperpolarized 129Xe using spiral‐IDEAL and MOXE in a model of regional radiation‐induced lung injury. Medical physics.
  23. Yao, W., Xu, Y., Liu, H.W. and Xia, K., 2017. Quantification of thermally induced damage and its effect on dynamic fracture toughness of two mortars. Engineering Fracture Mechanics, 169, pp.74-88.
  24. Woolman, M., Tata, A., Dara, D., Meens, J., D’Arcangelo, E., Perez, C.J., Prova, S.S., Bluemke, E., Ginsberg, H.J., Ifa, D. McGuigan, A., Ailes, L., and Zarrine-Afsar, A. 2017. Rapid determination of the tumour stroma ratio in squamous cell carcinomas with desorption electrospray ionization mass spectrometry (DESI-MS): a proof-of-concept demonstration. Analyst, 142(17), pp.3250-3260.
  25. Zanette, B., Stirrat, E., Jelveh, S., Hope, A. and Santyr, G., 2017. Detection of regional radiation-induced lung injury using hyperpolarized 129Xe chemical shift imaging in a rat model involving partial lung irradiation: Proof-of-concept demonstration. Advances in radiation oncology, 2(3), pp.475-484.
  26. Tabanfar, R., Qiu, J., Chan, H., Aflatouni, N., Weersink, R., Hasan, W. and Irish, J.C., 2017. Real‐time continuous image‐guided surgery: Preclinical investigation in glossectomy. The Laryngoscope, 127(10).
  27. Roberts, C.M., Shahin, S.A., Wen, W., Finlay, J.B., Dong, J., Wang, R., Dellinger, T.H., Zink, J.I., Tamanoi, F. and Glackin, C.A., 2017. Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models. Nanomedicine: Nanotechnology, Biology and Medicine, 13(3), pp.965-976.
  28. Belliveau, J.G., Jensen, M.D., Stewart, J.M., Solovey, I., Klassen, M.L., Bauman, G.S. and Menon, R.S., 2017. Prediction of radiation necrosis in a rodent model using magnetic resonance imaging apparent transverse relaxation (R 2*). Physics in medicine and biology.
  29. Maeda, A., Chen, Y., Bu, J., Mujcic, H., Wouters, B.G. and DaCosta, R.S., 2017. In vivo imaging reveals significant tumor vascular dysfunction and increased tumor hypoxia-inducible factor-1α expression induced by high single-dose irradiation in a pancreatic tumor model. International Journal of Radiation Oncology• Biology• Physics, 97(1), pp.184-194.
  30. Vidal, P.M., Karadimas, S.K., Ulndreaj, A., Laliberte, A.M., Tetreault, L., Forner, S., Wang, J., Foltz, W.D. and Fehlings, M.G., 2017. Delayed decompression exacerbates ischemia-reperfusion injury in cervical compressive myelopathy. JCI insight, 2(11).
  31. Fisher, C.J., Niu, C., Foltz, W., Chen, Y., Sidorova-Darmos, E., Eubanks, J.H. and Lilge, L., 2017. ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia. PloS one, 12(7), p.e0181654.
  32. He, C., Cai, P., Li, J., Zhang, T., Lin, L., Abbasi, A.Z., Henderson, J.T., Rauth, A.M. and Wu, X.Y., 2017. Blood-brain barrier-penetrating amphiphilic polymer nanoparticles deliver docetaxel for the treatment of brain metastases of triple negative breast cancer. Journal of Controlled Release, 246, pp.98-109.
  33. Zeng, K., Tian, L., Sirek, A., Shao, W., Liu, L., Chiang, Y.T., Chernoff, J., Ng, D.S., Weng, J. and Jin, T., 2017. Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression. Journal of molecular cell biology, 9(5), pp.384-394.
  34. Woolman, M., Ferry, I., Kuzan-Fischer, C.M., Wu, M., Zou, J., Kiyota, T., Isik, S., Dara, D., Aman, A., Das, S., Taylor, M.D., Rutka, J.T., Ginsberg H.J., and Zarrine-Afsar, A. 2017. Rapid determination of medulloblastoma subgroup affiliation with mass spectrometry using a handheld picosecond infrared laser desorption probe. Chemical science, 8(9), pp.6508-6519.
  35. Lu, Y., Boyle, A.J., Cao, P.J., Hedley, D., Reilly, R.M. and Winnik, M.A., 2017. EGFR-targeted metal chelating polymers (MCPs) harboring multiple pendant PEG2K chains for microPET/CT imaging of patient-derived pancreatic cancer xenografts. ACS Biomaterials Science & Engineering, 3(3), pp.279-290.
  36. Lai, P., Cai, Z., Pignol, J.P., Lechtman, E., Mashouf, S., Lu, Y., Winnik, M.A., Jaffray, D.A. and Reilly, R.M., 2017. Monte Carlo simulation of radiation transport and dose deposition from locally released gold nanoparticles labeled with 111In, 177Lu or 90Y incorporated into tissue implantable depots. Physics in Medicine & Biology, 62(22), p.8581.
  37. Aghevlian, S., Lu, Y., Winnik, M.A., Hedley, D.W. and Reilly, R.M., 2018. Panitumumab Modified with Metal-Chelating Polymers (MCP) Complexed to 111In and 177Lu–An EGFR-Targeted Theranostic for Pancreatic Cancer. Molecular pharmaceutics.
  38. Chang, Y.C.C., Ackerstaff, E., Tschudi, Y., Jimenez, B., Foltz, W., Fisher, C., Lilge, L., Cho, H., Carlin, S., Gillies, R.J. and Balagurunathan, Y., 2017. Delineation of tumor habitats based on dynamic contrast enhanced MRI. Scientific reports, 7(1), p.9746.
  39. Lam, K., Chan, C. and Reilly, R.M., 2017, January. Development and preclinical studies of 64Cu-NOTA-pertuzumab F (ab′) 2 for imaging changes in tumor HER2 expression associated with response to trastuzumab by PET/CT. In MAbs (Vol. 9, No. 1, pp. 154-164). Taylor & Francis.
  1. Wang, C. R., Mahmood, J., Zhang, Q. R., Vedadi, A., Warrington, J., Ou, N., … & Lu, Q. B. (2016). In Vitro and In Vivo Studies of a New Class of Anticancer Molecules for Targeted Radiotherapy of Cancer. Molecular Cancer Therapeutics, molcanther-0862.
  2. Au, B. C., Lee, C. J., Lopez-Perez, O., Foltz, W., Felizardo, T. C., Wang, J., … & Jaffray, D. A. (2016). Direct Lymph Node Vaccination of Lentivector/Prostate-Specific Antigen is Safe and Generates Tissue-Specific Responses in Rhesus Macaques. Biomedicines, 4(1), 6.
  3. Tata, A., Gribble, A., Ventura, M., Ganguly, M., Bluemke, E., Ginsberg, H. J., … & Zarrine-Afsar, A. (2016). Wide-field tissue polarimetry allows efficient localized mass spectrometry imaging of biological tissues. Chemical Science.
  4. Juneja, S. C., Viswanathan, S., Ganguly, M., & Veillette, C. (2016). A Simplified Method for the Aspiration of Bone Marrow from Patients Undergoing Hip and Knee Joint Replacement for Isolating Mesenchymal Stem Cells and In Vitro Chondrogenesis. Bone Marrow Research, 2016.
  5. Kim, S. M., Haider, M. A., Jaffray, D. A., & Yeung, I. W. (2016). Improved accuracy of quantitative parameter estimates in dynamic contrast-enhanced CT study with low temporal resolution. Medical physics, 43(1), 388-400.
  6. Dal Pra, A., Locke, J. A., Borst, G., Supiot, S., & Bristow, R. G. (2016). Mechanistic Insights into Molecular Targeting and Combined Modality Therapy for Aggressive, Localized Prostate Cancer. Frontiers in oncology, 6.
  7. Rodenhizer, Darren, et al. “A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients.”Nature materials 15.2 (2016): 227-234.
  8. Morrissy, A. Sorana, et al. “Divergent clonal selection dominates medulloblastoma at recurrence.” Nature 529.7586 (2016): 351-357.
  9. Edgar, L. J., Vellanki, R. N., McKee, T. D., Hedley, D., Wouters, B. G., & Nitz, M. (2016). Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution. Angewandte Chemie, 128(42), 13353-13357.
  10. Bilkey, J., Tata, A., McKee, T. D., Porcari, A. M., Bluemke, E., Woolman, M., … & Zarrine-Afsar, A. (2016). Variations in the Abundance of Lipid Biomarker Ions in Mass Spectrometry Images Correlate to Tissue Density. Analytical Chemistry, 88(24), 12099-12107.
  11. Moonen, G., Satkunendrarajah, K., Wilcox, J. T., Badner, A., Mothe, A., Foltz, W., … & Tator, C. H. (2016). A New Acute Impact-Compression Lumbar Spinal Cord Injury Model in the Rodent. Journal of neurotrauma, 33(3), 278-289.
  12. Stapleton, S., Mirmilshteyn, D., Zheng, J., Allen, C., & Jaffray, D. A. (2016). Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors. JoVE (Journal of Visualized Experiments), (114), e54226-e54226.
  13. Hammoud, L., Adams, J. R., Loch, A. J., Marcellus, R. C., Uehling, D. E., Aman, A., … & Egan, S. E. (2016). Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay. Stem cell reports, 7(4), 787-801.
  14. Her, S., Cui, L., Bristow, R. G., & Allen, C. (2016). Dual Action Enhancement of Gold Nanoparticle Radiosensitization by Pentamidine in Triple Negative Breast Cancer. Radiation research, 185(5), 549-562.
  15. Kostron, H., & Hasan, T. (Eds.). (2016). Photodynamic Medicine: From Bench to Clinic (Vol. 15). Royal Society of Chemistry.
  16. Sauvé, M., Hui, S. K., Dinh, D. D., Foltz, W. D., Momen, A., Nedospasov, S. A., … & Bolz, S. S. (2016). Tumor necrosis factor/sphingosine-1-phosphate signaling augments resistance artery myogenic tone in diabetes. Diabetes, db151450.
  17. Roberts, C. M., Shahin, S. A., Wen, W., Finlay, J. B., Dong, J., Wang, R., … & Glackin, C. A. (2016). Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models. Nanomedicine: Nanotechnology, Biology and Medicine.
  18. Sun, Y., & Chakrabartty, A. (2016). Cost-effective elimination of lipofuscin fluorescence from formalin-fixed brain tissue by white phosphor light emitting diode array. Biochemistry and Cell Biology, 94(6), 545-550.
  19. May, J. P., Hysi, E., Wirtzfeld, L. A., Undzys, E., Li, S. D., & Kolios, M. C. (2016). Photoacoustic Imaging of Cancer Treatment Response: Early Detection of Therapeutic Effect from Thermosensitive Liposomes. PLoS One, 11(10), e0165345.
  20. Yao, W., Xu, Y., Wang, W., & Kanopolous, P. (2016). Dependence of Dynamic Tensile Strength of Longyou Sandstone on Heat-Treatment Temperature and Loading Rate. Rock Mechanics and Rock Engineering, 49(10), 3899-3915.
  21. Patel, P., Kato, T., Ujiie, H., Wada, H., Lee, D., Hu, H. P., … & Yasufuku, K. (2016). Multi-Modal Imaging in a Mouse Model of Orthotopic Lung Cancer. PloS one, 11(9), e0161991.
  22. Muhanna, N., Cui, L., Chan, H., Burgess, L., Jin, C. S., MacDonald, T. D., … & Zheng, G. (2016). Multimodal Image-Guided Surgical and Photodynamic Interventions in Head and Neck Cancer: From Primary Tumor to Metastatic Drainage. Clinical Cancer Research, 22(4), 961-970.
  23. Stammes, M. A., Maeda, A., Bu, J., Scollard, D. A., Kulbatski, I., Medeiros, P. J., … & Chan, A. B. (2016). The necrosis-avid small Molecule hQ4-DTPa as a Multimodal imaging agent for Monitoring radiation Therapy-induced Tumor cell Death. Frontiers in oncology, 6.
  24. Zhou, B., Wang, L., Zhang, S., Bennett, B. D., He, F., Zhang, Y., … & Fargo, D. C. (2016). INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma. Genes & development, 30(12), 1440-1453.
  25. Prodger, J. L., Gray, R. H., Shannon, B., Shahabi, K., Kong, X., Grabowski, K., … & Reynolds, S. J. (2016). Chemokine Levels in the Penile Coronal Sulcus Correlate with HIV-1 Acquisition and Are Reduced by Male Circumcision in Rakai, Uganda. PLoS Pathogens, 12(11), e1006025.
  26. Rodenhizer, D., Cojocari, D., Wouters, B. G., & McGuigan, A. P. (2016). Development of TRACER: tissue roll for analysis of cellular environment and response. Biofabrication, 8(4), 045008.
  27. Lam, K., Chan, C., & Reilly, R. M. (2016, December). Development and preclinical studies of 64Cu-NOTA-pertuzumab F (ab′) 2 for imaging changes in tumor HER2 expression associated with response to trastuzumab by PET/CT. In mAbs (pp. 1-11). Taylor & Francis.
  28. Dou, Y. N., Dunne, M., Huang, H., Mckee, T., Chang, M. C., Jaffray, D. A., & Allen, C. (2016). Thermosensitive liposomal cisplatin in combination with local hyperthermia results in tumor growth delay and changes in tumor microenvironment in xenograft models of lung carcinoma. Journal of Drug Targeting, 24(9), 865-877.
  29. Matsumoto, Y., La Rose, J., Kent, O. A., Wagner, M. J., Narimatsu, M., Levy, A. D., … & Storozhuk, Y. (2016). Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. The Journal of Clinical Investigation, 126(12), 4482-4496.
  30. Ekdawi, S. N., Jaffray, D. A., & Allen, C. (2016). Nanomedicine and tumor heterogeneity: Concept and complex reality. Nano Today, 11(4), 402-414.

Workshops

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FEBRUARY 24, 2020

Imaging technology workshop in partnership with Soquelec, Bruker, and Spectral Instruments Imaging

Date: March 30 & 31, 2020 | 8am
THE EVENT IS POSTPONED.
We will update you about new dates as soon as possible.

Description: The workshop will provide researchers with an overview of preclinical imaging instrumentation, applications, contrast agents…

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November 1, 2018

STTARR PET/MRI workshop on December 3rd in partnership with Mediso and Siemens

Date: December 3, 2018 | 9:00am – 5:30pm
Description: STTARR will be holding a PET/MRI workshop this December 3rd to provide researchers with an overview of Preclinical PET/MRI imaging capabilities, contrast agents, translational and clinical studies.
Target Audience: Graduate students, technicians, research...

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June 19, 2018

STTARR pathology analysis workshop


Date: July 20, 2018 | 10:00am – 4:00pm
Description: This STTARR workshop is designed to inform and train interested parties in the use of Definiens TissueStudio image analysis software. The image analysis core of STTARR has many years of experience in utilizing Definiens TissueStudio platform, and custom-built post-processing analysis tools, that are…

Contact Us

STTARR Innovation Centre

The STTARR Innovation Centre is located at:
101 College Street, 7th floor
MaRS Building - East Tower
Princess Margaret Cancer Research Tower
Toronto, Ontario, M5G 1L7
Canada

Phone: (+1) 416-581-7770
Email: sttarr@rmp.uhn.ca
Homepage: www.sttarr.com

Questions?

STTARR can be accessed by any researcher, regardless of organization. Please contact us to discuss your project needs, or submit our Facility Access Request Form if you want to create a new project. Please submit our Facility Access Amendment Form whenever new Users or new Resources are added to an existing STTARR #.

Please contact us for a free consultation to discuss your research needs with a member of our expert team. Meeting and discussing your research and goals is the best way for us to ensure the right technology and/or equipment is applied to your project.

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The STTARR program appreciates the research funding from the following agencies.
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