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Driving development and research with state-of-the-art imaging resources

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STTARR Logo Reseach and Innovation Cores Logo

Driving development and research with state-of-the-art imaging resources

Get Started

Welcome to STTARR

Spatio-Temporal Targeting and Amplification of Radiation Response

The STTARR Innovation Centre brings together products, services and technologies to accelerate cutting-edge and multidisciplinary research in oncology, cardiology, metabolic diseases, and many other fields.

Flexible to the needs of our academic and industry clients, STTARR staff provides full support, from study conception to completion, including study design, budgeting, federal and provincial regulatory compliance, histopathology services, and advanced data analysis.

We focus on your success!

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6,642 ft 2

Research Space



Years of Experience






Researchers Working with STTARR


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Cutting-edge technologies for multidisciplinary research

STTARR’s advanced imaging instruments and experimental capabilities include CT, MR, PET, SPECT, ultrasound, photoacoustics, optical, and radiation therapy. The STTARR Correlative Pathology Laboratory is equipped with innovative technology enabling whole-mount pathology, thus preserving the geometric integrity of the sample and ensuring accurate correlation to in vivo imaging in a systematic way.

STTARR also has animal holding rooms, a cell culture facility, and dedicated wet lab space for developing new contrast agents, molecular probes, and radiotracers.


Sttarr offers the services and facilities needed for translational drug development and preclinical research.
Our services include:

For more information on Internal and External rates, please contact us or Naz Chaudary.

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Preclinical Imaging

Multimodal in vivo imaging in small and large animal models

  • Fluorescence and bioluminescence imaging
  • High resolution 3D ultrasound and photoacoustic imaging
  • Small animal 7T MRI
  • Clinical 1.5T MRI for imaging large animals
  • MR-guided HIFU at 1.5T and 7T
  • MicroCT imaging
  • Image-guided, flat-panel cone-beam CT radiation therapy units
  • Veterinary support through the Animal Resources Centre
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Radionuclides and Radiotracers

  • STTARR has expertise in:
    • radiolabeling proteins, antibodies, antibody fragments, liposomes, and other nanoparticles in one of its two Intermediate Level laboratories
    • performing pharmacokinetic and biodistribution studies
    • positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging
  • The STTARR Innovation Centre has a nuclear substances permit to possess, transfer, store and use:
    Ac-225, Au-198, Ba-133, C-11, Co-57, Cs-137, Cu-64, F-18, Ga-67, Ga-68, Hg-197, I-123, I-125, I-129, In-111, Lu-177, Mn-52, Tc-99m, Tl-201, Y-86, Y-90, and Zr-89
  • PET Radiotracers can be obtained from affiliates or commercial sources:
    F-18 FDG, F-18 FAZA, F-18 FCholine, F-18 DCFPyL(PSMA), F-18 Florbetaben, F-18 Sodium Fluoride (NaF), and F-18 FLT, Ga-68 DOTATATE
  • A selection of SPECT radiotracers include, but is not limited to the following: Tc-99m pertechnetate, Tc-99m MDP, Tc-99m HMPAO, Tc-99m DTPA, and Tc-99m MIBI

If your isotope or tracer is not mentioned, please talk to us !

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The STTARR's histopathology core now provides 100+ optimized antibodies for immunohistochemistry/immunofluorescence. The histopathology core now specializes in the special MOVAT stain (highlights the various constituents of connective tissue, especially cardiovascular tissue, by five colors in a single stained slide). The new development of an in-situ hybridization protocol combined with immunofluorescence or human X-Y chromosome assays is now a histopathology service offered at STTARR.

Services include:

▸ Formalin fixed Paraffin embedded (FFPE) tissue services
  • Grossing

    Inspect the samples for fixation statues, trimming harvest tissue to the plain of interest.

  • Tissue processing & embedding (regular and wholemount)

    Regular cassettes size is 30mm x 35mm.
    Supersize cassette for wholemount is 65mmX50mm.

  • Re-embedding

    Melt down paraffin block and re-orient the tissue into the desire cutting plain.

▸ Frozen tissue services
  • Cryo block sectioning

    Sectioning OCT frozen tissue blocks prepared by users.

  • Regular tissue specimen Freezing

    User provide fresh harvested tissue to STTARR Pathology for snap freezing in OCT.

  • Muscle Specimen Freezing

    Special snap freezing technique for muscle tissue prone to freeze artifact.

▸ Microtomy
  • Microtomy

    Sectioning paraffin and frozen section at routine 4um thickness or in special thickness requested by user.

  • Paraffin Microtomy

    Regular slides: 25mmx75mm.
    Wholemount large slide:50mmx75mm.

  • Serial sections

    Paraffin or frozen (per slide) consecutive sections from a ribbon of section mounted on slides labelled with numbers.

  • Specific micro-structure/Precise sectioning

    Look for specific microscopic structures in paraffin/frozen blocks and take sections eg. Mouse aortic arch, aortic root, mouse embryo thyroid glands.

▸ Immunohistochemistry
  • IHC New Antibody Optimization

    Optimization of commercial and/or in house produced antibodies.

  • Immunohistochemistry

    Check out our Pathology Optimized Antibody List for a list of antibodies currently available and optimized at STTARR Pathology. Please note that the list is continuously updated. If the antibody you are interested in is not on the list, please contact us.

  • Multiplex IF staining

    Multiplex of up to 3 target proteins in cells/tissues using flourescent tagged antibodies.

  • Tunel assay

    Detection of DNA fragmentation in last phase of apoptosis (cell death).

▸ In situ hybridization
  • In Situ Hybridization (RNAscope)

    Uitlizing ACDBio System probes and detection systems to detect target mRNA in paraffin embedded sections.

▸ Special Stains
  • Special Stains & Enzyme Histochemistry

    Masson trichrome, Elastic Trichrome, Picrosirius red,Periodic acid Schiff, Cresyl echt violet, Luxol fast blue, Gram stain, von Kossa calcium, Oil O red, Gordon & Sweets Siliver Reticular fiberstain, Safranin O and fast green, TRAP(Tartaric Acid Resistant Phosphotase).
    STTARR Pathology has other histochemistry stain protocols that are available upon request, please inquire if the stain that you are interested is not on the list.

▸ H&E staining

Principle and routine stain used in histopathology perform on paraffin or frozen sections.

▸ Other services
  • Autoradiography

    Sectioning thick sections (3--50microns) for autoradiography, 2 sets of slides each sample. Protocol on sample preparation for autoradiography available upon request.

  • Cell pellet agar embedding

    Centrifuge cell pellet and double embed into agar gel and paraffin.

  • Decalcification- acid

    Formic acid for rapid decalcification or EDTA for tissue to be used for IHC.

  • Full necropsy (Mouse, Rat, guinea pig)

    Havest tissue for toxicology study or specific organ of interest.

  • Tissue microarray construction

    Combining multiple donor tissue parrafin blocks into one for high throughput IHC staining.

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Consulting & Education

Scientific consulting & project management, workshops, user training and facility tours available

  • Our scientists provide comprehensive support throughout study conception, project management, method development, data analysis, and scientific & grant writing
  • We offer workshops on molecular imaging, user training sessions and facility tours. Please contact us for personalized workshop and training opportunities
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Translational Infrastructure

  • With two fully equipped operating rooms, intraoperative imaging capabilities (Fluoroscopy, Fluorescence Imaging), and a clinical bore size MRI with HIFU, STTARR provides infrastructure and offers support for translational research


Online resources


Our equipment is designed to facilitate multidisciplinary collaborations.

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CT combines a series of x-ray images taken from different angles around the subject or animal. Taking advantage of the differences in the x-ray attenuation properties of the various tissues and organs, computer processing creates cross-sectional images (slices) of the internal structures.

▸ Bruker SkyScan 1276
  • The Bruker SkyScan 1276 microCT system, located at UHN’s Krembil Discovery Tower and operated by STTARR, supports whole-body anatomical imaging of mice and rats in vivo, as well as high resolution studies of small excised samples (e.g. mouse femur, tibia) and non-biological samples
  • The SkyScan 1276 microCT has a maximum scan field of view that is 80 mm wide and more than 300 mm long. The highest nominal spatial resolution achievable is 2.8 µm pixel size for bone and tissue samples and approximately 10 µm for in vivo mouse studies
  • Physiological monitoring for time-resolved CT imaging (e.g. cardiac and respiratory gating) is available
▸ Mediso CT (As part of the SPECT-CT-PET trimodal system)
  • Mediso nanoScan SPECT-CT-PET is a triple modality system which also supports whole-body anatomical imaging of mice and rats at STTARR. CT scans can be easily co-registered to corresponding SPECT or PET scans
  • A 10 µm isotropic voxel size is the highest resolution possible for small (< 2 cm) field-of-view CT scans
▸ Clinical CT
  • GE Revolution Gen 2 ES (large animals) Spectral (dual-energy) CT allows for soft tissue differentiation without the use of contrast agents. Because of its fluoroscopy capabilities, researchers can perform image-guided biopsies and other interventional procedures.
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A MRI scan uses the magnetization from water protons to generate images in which brightness can reflect not only the density of water protons in tissue but also the interaction of water protons with their local microenvironment. These images provide an unparalleled soft tissue contrast, enabling both anatomic and functional imaging for monitoring tumor growth and response to therapies.

▸ 7 Tesla MRI (Biospec, Bruker)
  • By utilizing a range of RF and gradient coil inserts, it can accomodate animal models ranging in scale from ex vivo tissue samples and rodents, through to 5-7 kg animals
  • The machine capabilities are model-dependent, but can range from MR microscopy tasks (i.e. 60-micron isotropic voxels, using optimized RF coils and prolonged scanning sessions) through to standard techniques at high resolution for the relevant anatomy (i.e. 100x100x500-micron voxels in time-efficient murine brain scans; 500x500x1500-micron voxels in primates)
  • The STTARR-MRI can also accomodate multi-modal MR/CT/PET imaging in rodents utilizing the Minerve Small Animal Environment System

Note: The Bruker 7T MRI will be upgraded, in the Spring 2023, to the NEO architecture running ParaVision 360, which will provide safer operation, higher throughput imaging, longer hardware lifetimes, and best in-class fast imaging.

▸ MRgHIFU (LabFUS, Image Guided Therapy)
  • STTARR provides MR-guided high intensity focused ultrasound for both the 7 Tesla Bruker Biospec and 1.5 Tesla Siemens Aera MRI systems
  • The small animal MRgHIFU system for the Biospec includes two 25-mm diameter 8-element annular array transducers; a 1.5 MHz transducer suited for blood brain barrier disruption, and a 2.5 MHz transducer appropriate for hyperthermia or ablation applications. The large animal system includes a 145-mm diameter 256-element phased-array transducer operating at 1 MHz
  • For both small animal and large animal platforms, MRgHIFU feedback control based on real-time MR thermometry can be implemented through Proteus software
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Molecular Imaging

The nuclear medicine modalities of PET (Positron Emission Tomography) and SPECT (Single Photon Emission Computed Tomography) rely on injection (or sometimes inhalation) of a radioactive tracer. Nuclear medicine and molecular imaging techniques provide unique insight into the visualization, characterization, and measurement of biological processes at the molecular and cellular levels.

PET is a nuclear medicine imaging modality that detects the emissions of radiolabelled tracers. As positron-emitting isotopes decay, positrons interact with electrons in the subject. When a positron and electron interact, an annihilation event occurs in which the mass of these subatomic particles is converted into energy (E = mc2) in the form of two 511 keV gamma rays emitted at 180° apart from each other. These gamma ray pairs, resulting from annihilation events, are what is detected by the PET scanner.

SPECT is an imaging technique based on the detection of gamma rays emitted by radioactive tracers. The scanner consists of four gamma camera heads (scintillating sodium iodide crystals doped with thallium) with pinhole collimators that rotate around the subject. The SPECT computer reconstructs a 3-D tomographic image from the acquisition of 2-D images at multiple angles (projections). Isotopes useful for SPECT imaging emit gamma rays with energies between ~25 – 250 keV. They are high atomic number metals commonly used to label molecules of biological significance.

▸ PET/MRI – Mediso NanoScan
  • The Mediso NanoScan PET/MRI supports whole-body anatomic and physiological dynamic mouse and rat imaging at STTARR, including cardiac and respiratory gated PET and MRI
  • PET specifications: 0.9 mm spatial resolution (with reconstructed voxel sizes of 0.3, 0.4 or 0.6 mm)
  • MR specifications: 1 Tesla MRI, Gradient strength 450 mT/m, spatial resolution ≤ 100 µm with integrated gradient coil, RF and magnetic shielding
▸ SPECT-CT-PET – Mediso NanoScan
  • The Mediso NanoScan SPECT/CT/PET trimodal system supports whole-body mouse and rat imaging at STTARR. Dual-isotope SPECT imaging as well as gated SPECT and PET acquisitions are possible
  • SPECT parameters: spatial resolution varies depending on selected collimators, e.g. 1.1 mm (mouse - ultra-high sensitivity), 0.6 mm (mouse - ultra-high resolution) and 1 mm for rats
  • PET parameters: 0.9 mm spatial resolution (reconstructed voxel options: 0.3, 0.4 or 0.6 mm)
  • CT parameters: 10 µm minimum voxel size for a small field-of-view (e.g. mouse vertebra). Typically, a whole-body mouse CT takes less than 5 minutes for acquisition and reconstruction
▸ Wallac 1480 Wizard Gamma-Counter – PerkinElmer
  • The Wallac 1480 Wizard gamma-counter is an indispensible instrument for any pharmacokinetic or biodistribution experiment
  • 4π counting geometry for optimum efficiency, i.e. a 3-inch NaI(Tl) crystal surrounded by 3 inches of lead shielding, thus impenetrable to background radiation and crosstalk
  • Perfect for high energy (15 keV – 2 MeV), low activity samples
  • The researcher can count up to 20 mL/sample and up to 1000 samples/run using a library of 51 radionuclides
  • Counting racks can accommodate from 12×75 mm test tubes to 25 mm-diameter liquid scintillation vials
  • 2048-channel multichannel analyzer capable of back-decay and spilldown corrections
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Fluorescence and Bioluminesence imaging techniques.

▸ PerkinElmer Xenogen IVIS Spectrum Imaging System
  • Xenogen bioluminescence imaging provides the ability to detect luciferase-expressing cells with a high degree of sensitivity, making it particularly useful in for lower numbers of cells, for which fluorescence imaging may not be sensitive enough to separate signal from background autofluorescence
  • The quantitative or semi-quantitative nature of bioluminescence imaging also allows the tracking of the number of cells (or degree of luciferase expression) over time, with multiple injections of luciferin, lending itself well to applications such as monitoring of tumor burden over time
▸ CRI Maestro System
  • The CRI Maestro system is best used with known fluorophores, or transgenic cells expressing a fluorescent protein, growing subcutaneously within the murine model
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Real-time images are generated by applying high-frequency sound and then detecting the returning sound waves (echoes) caused by differences in acoustic impedence of the various tissue interfaces within the subject of interest. In addition to 2D B-mode images, anatomical 3D images of a small region can also be obtained. If the ultrasound beam is directed into a blood vessel, the blood flow gradient can be measured by a technique known as the Doppler effect. Visualization of blood flow can be further enhanced by the use of acoustic contrast agents such as microbubbles.

▸ Visualsonics Vevo 2100 System
  • Operates at frequency (20 to 40MHz) an order of magnitude above what is typically used in the clinic (1 to 5 MHz), which improves the resolution which is crucial for imaging small structures of a mouse
  • Features include 2D and 3D imaging, non-linear contrast imaging, M-mode, colour Doppler as well as pulsed-wave and continuous-wave Doppler
  • Transducers for mice and rat interrogation are the MS250 (13-24 MHz) and MS550D (22-55 MHz)
  • Heated mouse platform for regulating temperature and ECG-gating
  • Ultrasound-guided biopsy instrumentation
  • Vevo LAB software for quantifying and characterizing disease progression with specific applications
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The photoacoustic (PA) effect refers to the generation of acoustic waves from an object being illuminated by pulsed or modulated electromagnetic (EM) radiation, including optical waves. The fundamental principle of the PA effect is based on the thermal expansion resulting from the absorption of EM radiation. The thermal expansion increases the acoustic pressure in the medium. Pulsing or modulating the EM radiation generates an acoustic wave which can be detected using an ultrasound transducer.

▸ Visualsonics Vevo LAZR Photoacoustic Imaging System
  • A multi-component system which integrates laser light delivery with ultrasound image acquisition to produce photoacoustic image data
  • Uses a 20Hz tunable laser (680 – 970nm) to image functional hemodynamic and molecular data with a resolution down to 40 µm and a depth of 1 cm
  • Transducers for mice and rat interrogation are the MZ250 (13-24 MHz) and MZ550 (32-55 MHz)
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Small Animal Irradiator

STTARR has installed the new SmART+ system, the small animal irradiator at PMCRT.

▸ SmART+ system
  • Mimicking clinical radiotherapy imaging and treatments, our Small Animal Radiation Therapy (SmART+) systems bring a highly sophisticated, expandable platform to the field of preclinical research. Together, with easy-to-use software and an advanced set of imaging modalities, including Cone-Beam CT, µCT and Bioluminescence (BLI), this state-of-the-art focal irradiation system is the perfect tool for image-guided radiation research.
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Software and Analysis Workstations

STTARR's Image Analysis Core provides both self-service workstations and dedicated technician analysis of medical images coming from the STTARR facility scanners, as well as digital pathology and mass spectrometry image analysis. Our team can guide you through the available options and provide software training as needed.

▸ High-performance computing workstations
  • 6 computer workstations are available with a wide variety of analysis software
  • General specs: Intel Xeon CPUs, 32 GB RAM, CUDA-enabled NVIDIA GPUs
  • High-speed on-site data server allows for secure large file storage
▸ Pathology image analysis software
  • Commercial software packages can be used for high-throughput analysis of digitized whole slide images including performing classification of various tissue types and cell counting
  • Definiens TissueStudio and Developer
▸ Radiology image analysis software
  • Siemens Inveon Research Workplace (IRW)
  • InviCRO VivoQuant volumetric analysis software


Initial of Naz Chaudary

Naz Chaudary, PhD

Core Manager, STTARR Innovation Centre
Staff Scientist

Pre-Clinical Imaging Core

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Deborah Scollard

Pre-clinical Imaging core Manager
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Warren Foltz, PhD

MRI Lead
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Teesha Komal

Imaging Technologist
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Luke Kwon, PhD

Scientific Associate
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Alex Wang

Research Technician
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Doug Vines

Nuclear Imaging Scientist
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Steve Ansell

Computational Consultant

Histopathology Core

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Napoleon Law

Histopathology Core Lead
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Feryal Sarraf

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Jordi Ros Rodriguez

picture of Paulnin Rouize S. Barbanida

Paulnin Rouize S. Barbanida

(Pronouns: he or she)
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Catherine Williams

Administrative Assistant


We kindly request for authors who use STTARR resources to include the following acknowledgement in their publication:
“The authors would like to acknowledge the Spatio-Temporal Targeting and Amplification of Radiation Response (STTARR) program and its affiliated funding agencies.”

Select a year to see a listing of articles published.

  1. Constantine J. Georgiou, Zhongli Cai, Noor Alsaden, Hyungjun Cho, Minou Behboudi, Mitchell A. Winnik, James T. Rutka, and Raymond M. Reilly (2022). Treatment of Orthotopic U251 Human Glioblastoma Multiforme Tumors in NRG Mice by Convection-Enhanced Delivery of Gold Nanoparticles Labeled with the β-Particle-Emitting Radionuclide, 177Lu.
  1. Rezaeeyan, H., Shirzad, R., McKee, T. D., & Saki, N. (2018). Role of chemokines in metastatic niche: new insights along with a diagnostic and prognostic approach. Apmis .
  2. Alhamami, M., Cheng, W., Lyu, Y., Allen, C., Zhang, X.A. and Cheng, H.L.M., 2018. Manganese-porphyrin-enhanced MRI for the detection of cancer cells: A quantitative in vitro investigation with multiple clinical subtypes of breast cancer. PloS one, 13(5), p.e0196998.
  3. Bteich, J., Ernsting, M.J., Mohammed, M.Z., Kiyota, T., McKee, T., Trikha, M., Lowman, H. and Sokoll, K.K., 2018. A Novel Nanoparticle Formulation Derived from Carboxymethyl-Cellulose, Polyethylene Glycol and Cabazitaxel for Chemotherapy Delivery to the Brain. Bioconjugate chemistry .
  4. Dhani, N.C., Lohse, I., Foltz, W.D., Cao, P.J. and Hedley, D.W., 2018. Estimating tumour volume in a primary orthotopic mouse model of human pancreatic cancer using rapid acquisition magnetic resonance imaging. journal of cancer therapeutics and research, 3(1), p.9.
  5. Rezaeeyan, H., Shahrabi, S., McKee, T.D. and Saki, N., 2018. The expression of CD markers in solid tumors: Significance in metastasis and prognostic value. Histology and histopathology , pp.11981-11981.
  6. Li, H., Xie, Y., Liu, Y., Qi, Y., Tang, C., Li, X., Zuo, K., Sun, D., Shen, Y., Pang, D. and Chu, Y., 2018. Alteration in microRNA-25 expression regulate cardiac function via renin secretion. Experimental cell research , 365 (1), pp.119-128.
  7. He, C., Li, J., Cai, P., Ahmed, T., Henderson, J.T., Foltz, W.D., Bendayan, R., Rauth, A.M. and Wu, X.Y., 2018. Two‐Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2‐Positive Breast Cancer. Advanced Functional Materials .
  8. Shahin, S.A., Wang, R., Simargi, S.I., Contreras, A., Echavarria, L.P., Qu, L., Wen, W., Dellinger, T., Unternaehrer, J., Tamanoi, F. and Zink, J.I., 2018. Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer. Nanomedicine: Nanotechnology, Biology and Medicine, 14 (4), pp.1381-1394.
  9. Teichman, J., Dodbiba, L., Thai, H., Fleet, A., Morey, T., Liu, L., McGregor, M., Cheng, D., Chen, Z., Darling, G. and Brhane, Y., 2018. Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma. PloS one , 13 (5), p.e0194809.
  10. Haynes, J., McKee, T.D., Haller, A., Wang, Y., Leung, C., Gendoo, D.M., Lima-Fernandes, E., Kreso, A., Wolman, R., Szentgyorgyi, E. and Vines, D.C., 2018. Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer. Clinical Cancer Research .
  11. Beera, K.G., Li, Y.Q., Dazai, J., Stewart, J., Egan, S., Ahmed, M., Wong, C.S., Jaffray, D.A. and Nieman, B.J., 2018. Altered brain morphology after focal radiation reveals impact of off-target effects: implications for white matter development and neurogenesis. Neuro-oncology , 20 (6), pp.788-798.
  12. Zanette, B., Stirrat, E., Jelveh, S., Hope, A. and Santyr, G., 2018. Physiological gas exchange mapping of hyperpolarized 129Xe using spiral‐IDEAL and MOXE in a model of regional radiation‐induced lung injury. Medical physics , 45 (2), pp.803-816.
  13. Tang, Q., Lu, J., Zou, C., Shao, Y., Chen, Y., Narala, S., Fang, H., Xu, H., Wang, J., Shen, J. and Khokha, R., 2018. CDH4 is a novel determinant of osteosarcoma tumorigenesis and metastasis. Oncogene , p.1.
  14. Yang, C., Bromma, K., Ciano-Oliveira, C., Zafarana, G., Prooijen, M. and Chithrani, D.B., 2018. Gold nanoparticle mediated combined cancer therapy. Cancer Nanotechnology , 9 (1), p.4.
  15. Inoue, M., Enomoto, M., Koike, Y., Di Grappa, M.A., Zhao, X., Yip, K., Huang, S.H., Waldron, J.N., Ikura, M., Liu, F.F. and Bratman, S.V., 2018. Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis. bioRxiv , p.273037.
  16. Xia, D., Casanova, R., Machiraju, D., McKee, T.D., Weder, W., Beck, A.H. and Soltermann, A., 2018. Computationally-Guided Development of a Stromal Inflammation Histologic Biomarker in Lung Squamous Cell Carcinoma. Scientific reports , 8 (1), p.3941.
  17. Dunne, Michael, Yannan N. Dou, Danielle M. Drake, Tara Spence, Sávio ML Gontijo, Peter G. Wells, and Christine Allen. “Hyperthermia-mediated drug delivery induces biological effects at the tumor and molecular levels that improve cisplatin efficacy in triple negative breast cancer.” Journal of Controlled Release (2018).
  18. Young, M., Rodenhizer, D., Dean, T., D’Arcangelo, E., Xu, B., Ailles, L. and McGuigan, A.P., 2018. A TRACER 3D Co-Culture tumour model for head and neck cancer. Biomaterials , 164 , pp.54-69.
  19. Aghevlian, S., Lu, Y., Winnik, M.A., Hedley, D.W. and Reilly, R.M., 2018. Panitumumab Modified with Metal-Chelating Polymers (MCP) Complexed to 111In and 177Lu–An EGFR-Targeted Theranostic for Pancreatic Cancer. Molecular pharmaceutics .
  20. Yao, W., Xia, K. and Liu, H.W., 2018. Influence of heating on the dynamic tensile strength of two mortars: Experiments and models. International Journal of Impact Engineering, 122, pp.407-418.
  21. Haynes, J., McKee, T.D., Haller, A., Wang, Y., Leung, C., Gendoo, D.M., Lima-Fernandes, E., Kreso, A., Wolman, R., Szentgyorgyi, E. and Vines, D.C., 2018. Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer. Clinical Cancer Research.
  22. Stapleton, S., Dunne, M., Milosevic, M., Tran, C.W., Gold, M.J., Vedadi, A., Mckee, T.D., Ohashi, P.S., Allen, C. and Jaffray, D.A., 2018. Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics. ACS nano, 12(8), pp.7583-7600.
  23. Bernards, N., Ventura, M., Fricke, I.B., Hendriks, B.S., Fitzgerald, J., Lee, H. and Zheng, J., 2018. Liposomal Irinotecan Achieves Significant Survival and Tumor Burden Control in a Triple Negative Breast Cancer Model of Spontaneous Metastasis. Molecular Pharmaceutics, 15(9), pp.4132-4138.
  24. Belliveau, J.G., Jensen, M.D., Stewart, J.M., Solovey, I., Klassen, L.M., Bauman, G.S. and Menon, R.S., 2018. Prediction of radiation necrosis in a rodent model using magnetic resonance imaging apparent transverse relaxation (). Physics in Medicine & Biology, 63(3), p.035010.
  25. Yoshida, M., Oishi, H., Martinu, T., Hwang, D.M., Takizawa, H., Sugihara, J., McKee, T.D., Bai, X., Guana, Z., Lua, C. and Cho, H.R., 2018. Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model. Oncotarget, 9(9), p.8489.
  26. Yang, C., Bromma, K., Di Ciano-Oliveira, C., Zafarana, G., van Prooijen, M. and Chithrani, D.B., 2018. Gold nanoparticle mediated combined cancer therapy. Cancer Nanotechnology, 9(1), p.4.
  27. Tang, Q., Lu, J., Zou, C., Shao, Y., Chen, Y., Narala, S., Fang, H., Xu, H., Wang, J., Shen, J. and Khokha, R., 2018. CDH4 is a novel determinant of osteosarcoma tumorigenesis and metastasis. Oncogene, p.1.
  28. Harmatys, K.M., Overchuk, M., Chen, J., Ding, L., Chen, Y., Pomper, M.G. and Zheng, G., 2018. Tuning Pharmacokinetics to Improve Tumor Accumulation of a Prostate-Specific Membrane Antigen-Targeted Phototheranostic Agent. Bioconjugate Chemistry, 29(11), pp.3746-3756.
  29. Keca, J.M., Valic, M.S., Cheng, M.H., Jiang, W., Overchuk, M., Chen, J. and Zheng, G., 2018. Mixed and Matched Metallo‐Nanotexaphyrin for Customizable Biomedical Imaging. Advanced healthcare materials, p.1800857.
  30. Al-saden, N., Cai, Z. and Reilly, R.M., 2018. Tumor uptake and tumor/blood ratios for 89Zr-DFO-trastuzumab-DM1 on microPET/CT images in NOD/SCID mice with human breast cancer xenografts are directly correlated with HER2 expression and response to trastuzumab-DM1. Nuclear medicine and biology, 67, pp.43-51.
  31. Al-Saden, N., Lam, K., Chan, C. and Reilly, R.M., 2018. Positron-Emission Tomography of HER2-Positive Breast Cancer Xenografts in Mice with 89Zr-Labeled Trastuzumab-DM1: A Comparison with 89Zr-Labeled Trastuzumab. Molecular pharmaceutics, 15(8), pp.3383-3393.
  32. Islam, D., Huang, Y., Fanelli, V., Delsedime, L., Wu, S., Khang, J., Han, B., Grassi, A., Li, M., Xu, Y. and Luo, A., 2018. Identification and Modulation of Microenvironment is Crucial for Effective MSC Therapy in Acute Lung Injury. American journal of respiratory and critical care medicine, (ja).
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picture of magnetic insight workshop poster
May 12, 2021

Magnetic Particle Imaging: An Introduction and Applications Presentation

Date: May 20, 2021 | 4pm (1 hour)


Description: Results from immune cell tracking, in vivo quantitation, drug-delivery monitoring, inflammation quantitation, and localized hyperthermia will be discussed…

picture of imaging workshop poster
FEBRUARY 24, 2020

Imaging technology workshop in partnership with Soquelec, Bruker, and Spectral Instruments Imaging

Date: March 30 & 31, 2020 | 8am
We will update you about new dates as soon as possible.

Description: The workshop will provide researchers with an overview of preclinical imaging instrumentation, applications, contrast agents…

picture of Mri
November 1, 2018

STTARR PET/MRI workshop on December 3rd in partnership with Mediso and Siemens

Date: December 3, 2018 | 9:00am – 5:30pm
Description: STTARR will be holding a PET/MRI workshop this December 3rd to provide researchers with an overview of Preclinical PET/MRI imaging capabilities, contrast agents, translational and clinical studies.
Target Audience: Graduate students, technicians, research...

Contact Us

STTARR Innovation Centre

The STTARR Innovation Centre is located at:
101 College Street, 7th floor
MaRS Building - East Tower
Princess Margaret Cancer Research Tower
Toronto, Ontario, M5G 1L7

Phone: (+1) 416-581-7771


STTARR can be accessed by any researcher, regardless of organization. Please contact us to discuss your project needs, or submit our Facility Access Request Form if you want to create a new project. Please submit our Facility Access Amendment Form whenever new Users or new Resources are added to an existing STTARR #.

Please contact us for a free consultation to discuss your research needs with a member of our expert team. Meeting and discussing your research and goals is the best way for us to ensure the right technology and/or equipment is applied to your project.


The STTARR program appreciates the research funding from the following agencies.
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